Endocrine Abstracts

Incidental thyroid carcinoma includes thyroid carcinomas detected after surgery in patients whose thyroid has been correctly studied with no data of malignancy. Lately, the widely spread use of image techniques and thorough search of thyroid nodule complains, have lead to a growing number of thyroid carcinomas. But still there are some of these incidentally discovered after thyroidectomy.We report 98 cases of thyroid carcinomas incidentally found from a ...

Bilateral cervical exploration has been the gold standard in parathyroid surgery. Nowadays, the preoperative localization procedures have facilitated the minimally invasive surgery. This study aims to analyze the influence of thyroid disease in Tc99m-sestamibi scintigraphy (MIBI) results.A series of 154 patients with PHP who underwent parathyroidectomy was reviewed. Patients were divided into two groups: group 1 (G1, 58 patients) with thyroid diseases, a...

Objective: To determine the prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism and their relationships with metabolic syndrome (MS) parameters in female-to-male transsexuals (FMT).Design and methods: Seventy-seven FMT were assessed clinically and biochemically to hyperandrogenism, before the beginning of the treatment with testosterone. We also assessed cardiovascular risk factors and other parameters of MS.Results...

Aims/hypothesis: Adrenal incidentaloma (AI) are very common, but optimal management of patients with AI and low-grade excess cortisol secretion is not established. Uncontrolled studies reporting outcomes of adrenalectomy suggest improvements in cardiovascular risk, but all are subject to selection bias, and it is unclear if benefits are due to removal of excess cortisol. We reasoned that short-term use of mifepristone, a rapidly-acting glucocorticoid receptor (GR) antagonist, ...

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcaemia in the outpatient setting. Surgical remove of an adenoma or hyperplastic glands results in cure, but an accurate localization, preoperative whenever possible, is essential for success. Taking into consideration that parathyroid carcinoma is a rare event, FNA of parathyroid glands, complemented by PTH measurement in washouts (FNA/PTH), may be a useful tool in the diagnostic workout.<...

Current treatment for acromegaly includes dopamine agonists (DA), somatostatin receptor ligands (SRL) and GH receptor antagonists (GHRA). DA in monotherapy, is less than 10% effective achieving control of the disease, and its efficacy in addition to ongoing SRL is less studied, without obvious determining factors of response. We report 2 operated patients with incomplete response to SRL and to whom Cabergoline addition led to disease control.Case 1: A ma...

Background: Although acyl–ghrelin has been considered essential for ghrelin’s GH-releasing activity, several recent in vitro studies have shown that desacyl–ghrelin exhibits biological activities on metabolism and proliferation of adipocytes, myocytes, cardiomyocytes, and myelocytes. The full desacyl–ghrelin biological activity still remains a matter of debate.Aims: To assess desacyl–ghrelin circulating levels and its R51Q...

Background: Adiponectin is an adipokine with anti-diabetic properties. Recently, retinol binding protein-4 (RBP4) was identified as an adipokine associated with insulin resistance (IR) and a potential marker for type 2 diabetes (T2D) development.Aims: To compare adiponectin and RBP4 circulating levels according to presence/absence of diabetes/prediabetes, in obese women. To study the degree of association of those adipokines with indexes of IR and insuli...

Autoimmune polyendocrinopathy syndromes (APS) gather a wide range of diseases. The association of autoimmune thyroid disease (ATD) with other organ specific diseases is frequent. Atrophic body gastritis (ABP) is characterized by the loss of ClH and intrinsic factor (IF) production. Both ATD and ABP are known to be associated since 1960 but there are scarce publications describing its clinical features.We review patients with this association selected fro...

Background: The Endocrine Society clinical practice guidelines suggest use of the 1 mg overnight dexamethasone suppression test (ONDST) to screen for cortisol excess in patients with adrenal incidentalomas, followed by the 48-h, 2 mg/day, low-dose dexamethasone-suppression test (LDDST), to confirm a positive result. Visceral fat accumulates in cortisol-excess and accounts for increased cardiovascular risk. In this study, we investigate whether the LDDST offers additional infor...